Indrapal Singh Aidhen

Professor

Chemistry ,

2015-2018: Head of Department

2006 -present: Professor

1995: Assistant Professor

+91-44-2257-4219

isingh@iitm.ac.in

http://chem.iitm.ac.in/faculty/indrapal/

Research Areas

  • Synthetic Carbohydrate Chemistry

  • Synthesis of Biologically/Medicinally Important Compounds

  • Developing New Building Blocks based on Weinreb - amide Functionality

  • Developing Enantiopure Chiral Building Blocks


Selected Journal Publications

  • Effects of spatial resolution on WRF v3.8.1 simulated meteorology over the central Himalaya Sachin S. Gunthe,  Singh J., Indrapal Singh Aidhen, Ravi Kumar,Rao Kotamarthi V. (8 authors) 2021 | EGU


  • Aidhen, I. S. (2020). ‘Bioactive C-Glycosides inspired from Natural Products Towards Therapeutics’ in Tiwari, V. K. (ed.) Carbohydrates in Drug Discovery and Development. Amsterdam, Netherlands: Elsevier, pp. 97- 153.


  •  Synthesis of Benzyl C-Analogues of Dapagliflozin as Potential SGLT2 Inhibitors Mukkamala, R.; Kumar, R.; Banerjee, S. K.; Aidhen, I. S., Eur. J. Org. Chem., 2020, 1828–1839.


  • Novel Chemical Scaffolds to Inhibitthe Neutral Amino Acid TransporterB0AT1 (SLC6A19), a Potential Targetto Treat Metabolic Diseases, Yadav, A; Shah, N.;Tiwari, P. K.; Javed, K.; Cheng, Q.; Aidhen, I. S.; Bröer, S. Front. Pharmacol.2020, 11:140, 1-13.


  • Acyl and Benzyl-C-β-D-Glucosides: Synthesis and Biostudies for Glucose-Uptake-Promoting Activity in C2C12 Mytotubes, Reddy, M. R.; Hemaiswarya, S.; Kommidi, H.; Aidhen, I. S.; Doble, M. Eur. J. Org. Chem., 2019, 6053–6070.


  • Synthesis of 4-C-_-D-GlucosylatedIsoliquiritigenin and Analogues for Aldose Reductase Inhibition StudiesReddy, M. R., Aidhen, I. S.; Reddy, U. A.; Reddy, G. B.; Ingle, K.; Mukhopadhyay, S., Eur. J. Org. Chem., 2019, 3937–3948.


  • Discovery of an IsocoumarinAnalogue that Modulates Neuronal Functions via NeurotrophinReceptor TrkB, Bioorg. Med. Chem. Lett., 2019, 29, 585-590.

Research Projects

  • Synthetic Carbohydrate Chemistry 

  • Synthesis of Biologically/Medicinally Important Compounds 

  • Developing New Building Blocks based on Weinreb-amide Functionality

  • Developing Enantiopure Chiral Building Block

        Patents

  • Synthesis Of Amorfrutin And Cajaninstilbense And Their Analogues From A Common Building Block Aidhen Indrapal Singh | *Mukkamala Ramesh Patent No. In328436b  Published Filed 2013-11-27  Published 2020-01-03


  • A new dye for application in dye laser and nonlinear optics and as a fluorescence lifetime standard Bisht, Prem B.; Aidhen, I. S. Indian Pat. Appl. 2010, IN 2008CH02643 A 20100507


  • Process for preparation of (βS,4R)- 2,2-dimethyl-β-benzyloxy-1,3-dioxolane-4-ethanol Aidhen, I. S.; Vijayasaradhi, S. Indian Pat. Appl. 2007, IN 2002MA00543 A 20070511.


  • One pot conversion of D-erythronolactone to enantiomerically pure alkyl (S)-4-bromo-3-hydroxybutanoate Aidhen, I. S.; Gurjar, M. K.; Mahalingam, S. M. Indian Pat. Appl. 2006, IN 2004DE02174 A 20060818.

Awards & Recognitions

  • 2016 Professor S. Swaminathan Endowment Award Lecture

  •  2015 Trends In Carbohydrate Research Award - ACCTI

  • 2014 Excellence In Carbohydrate Research Award - ACCTI

  • 2013 Elected Member National Academy Of Sciences, Allahabad

  • 1993-1995 Alexander Von Humboldt Fellow Award From Germany

  • 2004- Japan Society for the Promotion of Science  Invitation Fellowship, Japan

  • 2003 - 2004 JSPS Invitation Fellowship Award From Japan

  • 2001- Invitation, University Of Utah, Salt Lake City, USA

  • 1995-Alexander Von Humboldt Fellowship,Germany

  • 1985-1990-Research Fellowship Award From CSIR New Delhi

  • 1981-1983- National Merit Scholarship Award After Graduation